Confusion between salt / freebase - the Hive BB

Confusion between salt / freebase

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Author	Topic: Confusion between salt / freebase
metical Member	posted 12-05-1999 04:08 PM Since I still am fairly new to this, what is the difference between salt and freebase E?...Im guessing that the HCl Salt is when during the A/B extraction you lower the ph to 7.2 with HCl. Now if someone wanted freebase (only in dreams of course) would they just stop before adding the HCl and evaporate the fuel (naphtha)?..are there any other ways one might get freebase pseudo-E..and yes I have used the search engine, I just need a clear explanation... -Sippin on Tical
Worlock Member	posted 12-05-1999 07:58 PM In a basic solution of pH-12.4 and higher pseudoephedrine-HCl(salt) looses a H+ from the amino side chain. This makes the ephedrine no longer soluble in water, it also drops the CL- which was attracted to the H+. and is no longer the HCl salt of pseudo-ephedrine, It is then called the free base, by most who work with it. This is oil soluble and floats to the top of the water. When naphtha, toluene, ether or a non polar solvent is used the freebase dissolves in the fuel(oil solvent), the basic solution of water uis removed and if you evaporate the non-polar crystals of ephedrine free base appear. It is possible to separate the pseudo free base from the water without the use of non polar solvent. An ounce or more of sudo makes it easier since the sodo will bunch together and you will be able to clearly see it on top of the water. Other methods besides evaporation include crystalization, A large amoount of sudo freebase will dissolve in a small amount of fuel solvent, especially if the solvent and pseudo are warmed up carefully, the sudo will readily crystalize out of the solution as it is chilled, or transferred to a cold container the sudo will crystalise on the walls of the cold vessel immediately, the effect with naptha is is quite impressive.
metical Member	posted 12-05-1999 08:20 PM Thanks a lot, once again worlock saves the day for me...It's a good thing I bought that tub of naphtha from the hardware store on friday...how warm does the naphtha be before I add it to the water solution in the sepatory funnel?...After I shake and the two layers seperate( Im using a real 60 ml sep funnel one of my chemist freinds let me borrow)...do I drain off the water soltuion by turning the knob so the little hole is even with the opening?
SunriseSpecial Member	posted 12-05-1999 10:26 PM Metical: Naptha works, but I and many other bees have found that toluene is wayyyy better.
swarm unregistered	posted 12-06-1999 12:50 AM lets consider the waekness of the question shall we???????????? What if anything might be found humm??????? not a dam thing???????//////////////// Ok so lets consider the rearangement of the ammine meterial shall we????????? What if any protection is afforded the +NHCH3 freebase? NONE part of the molecule byebye say possibly causing it to haloid salt up? like this MIGHT BE A GOOD IDEA HUMMM? .............[HI](g) (-)NH-----CH3>>>>>>>>>thus yielding the [HI]SALT^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^ ook So ya got want what ya get the iodine salt this is soluable in water>>>>>>>>>>> ...(+)..... [H-N-H]]]]I(-) now further in to the ring of it is a ch unit in any case ya might want to do something as far as the theory goes there is power in theory power to judge To arrive at conclusion hummm? there is an CH unit this is granted,,,c is occupied by and in relation is hanging on to a bond that is easilly broken and reformed>>>>>>>>>>>>............ thus the c=o this is simple hummm well -C- thats two and C needs four so -C- is it OH is it oH is it OH ?????????????????????????????????//// Well maybe it is what if this ......................... ........H............. ......H-CH........... ........H.............. ....................... aint um very explanitive?????????/
CHEMMAN Member	posted 12-06-1999 05:33 AM Hang on swarm.I get your point but he speaks of Ephedrine freebase .So where did HI come in .Later perhaps??
Quennie Junior Member	posted 12-25-1999 04:52 AM Metical, in a sense you are right. The freebase form of the drug is the unneutralized form, it is still an amine in particular or freebase in general term. If it pH of your solution is above 10 , preferably 12, you can be pretty sure that all your drug is in the freebase form. Now, when you add acid, you are neutralizing the base( the freebase or the amine)to make a salt form of the drug. Ideal pH for the formation of your final salt would be between 6 or 7. However, if you are still doing an acid/base extraction add more acid until the pH reaches 2 or the blue litmus paper truns really red. In this way, you can get all of your freebase in the salt form.
makin personal Member	posted 12-25-1999 03:45 PM then what do you do with this acid salt. Damn this shit is confusing??????

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